Verify Account

SYLLABUS

Unit-I

Controlled Drug Delivery Systems: Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates. Approaches to design controlled release formulations based on diffusion, dissolution and ion exchange principles. Physico-chemical and biological properties of drugs relevant to controlled release formulations. Polymers: Introduction, classification, properties, advantages and application of polymers in formulation of controlled release drug delivery systems.

Unit-II

Microencapsulation: Definition, advantages and disadvantages, microspheres/microcapsules, microparticles, methods of microencapsulation, applications. Mucosal Drug Delivery Systems: Introduction, principles of bioadhesion/mucoadhesion, concepts, advantages and disadvantages, transmucosal permeability and formulation considerations of buccal delivery systems. Implantable Drug Delivery Systems: Introduction, advantages and disadvantages, concept of implants and osmotic pump.

Unit-III

Transdermal Drug Delivery Systems: Introduction, permeation through skin, factors affecting permeation, permeation enhancers, basic components of TDDS, formulation approaches. Gastroretentive Drug Delivery Systems: Introduction, advantages, disadvantages, approaches for GRDDS - floating, high density systems, inflatable and gastroadhesive systems and their applications. Nasopulmonary Drug Delivery Systems: Introduction to nasal and pulmonary routes of drug delivery, formulation of inhalers (dry powder and metered dose), nasal sprays, nebulizers.

Unit-IV

Targeted Drug Delivery: Concepts and approaches, advantages and disadvantages, introduction to liposomes, niosomes, nanoparticles, monoclonal antibodies and their applications.

Unit-V

Ocular Drug Delivery Systems: Introduction, intra ocular barriers and methods to overcome - preliminary study, ocular formulations and ocuserts. Intrauterine Drug Delivery Systems: Introduction, advantages and disadvantages, development of intrauterine devices (IUDs) and applications.